Leukotrienes biosynthesis in coronary artery disease - results of Leukotrienes and Thromboxane In Myocardial Infarction (LTIMI) study
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چکیده
منابع مشابه
Urinary 11‐Dehydro‐Thromboxane B2 as a Predictor of Acute Myocardial Infarction Outcomes: Results of Leukotrienes and Thromboxane In Myocardial Infarction (LTIMI) Study
BACKGROUND Urinary 11-dehydro-thromboxane (TX)B2 has been described as a potential predictive biomarker of major adverse cardiovascular events (MACEs) in high cardiac risk patients. This part of LTIMI (Leukotrienes and Thromboxane In Myocardial Infarction) study aimed to evaluate the relationship between 11-dehydro-TXB2 and MACEs in patients with acute myocardial infarction (AMI). METHODS AND...
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Background: Inflammation plays a critical role in atherogenesis. The initial step in atherosclerosis is the adhesion of leukocytes to activated endothelial cells mediated by ICAM-1, an inflammatory protein. Several polymorphisms for Intracellular adhesion molecule -1(ICAM-) gene have been described. Objective: To determine the possible role of G241R and K469E polymorphisms in development of cor...
متن کاملBiosynthesis and metabolism of leukotrienes.
Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO is LTA4 (leukotriene A4), which is enzymatically converted into either LTB4 (leukotriene B4) by LTA4 hydrolase or LTC4 (leukotriene C4) by LTC4 synthase. The regulation of leukotriene production occurs at various levels, including expression of 5-LO, translocation of ...
متن کاملBiosynthesis of leukotrienes in canine cerebral vasospasm.
We produced cerebral vasospasm in 29 dogs by the "two-hemorrhage" method of intracisternal injections, 2 days apart, of autogenous arterial blood. Leukotriene (LT) C4, LTD4, and LTE4 were purified from incubated basilar artery, medulla oblongata, hypothalamus, median eminence, and blood clot from around the basilar artery using reverse-phase high-performance liquid chromatography, and the amoun...
متن کاملBiosynthesis and Biological Role of Leukotrienes in B Lymphocytes
Human B lymphocytes have similar capacity to produce leukotriene (LT) B4 as myeloid cells but the biological function of the 5-lipoxygenase (5-LO) pathway in B cells is unclear. In order to better understand the role of 5-LO and LTB4 in B cells we investigated which subsets of normal B cells from tonsils that expressed 5-LO. Based on immunostaining with a polyclonal antibody raised against 5-LO...
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ژورنال
عنوان ژورنال: Polish Archives of Internal Medicine
سال: 2017
ISSN: 1897-9483
DOI: 10.20452/pamw.4140